how to save data inserted from the datagrid view into the database

i am using sql as my back end and vb.net as my front end..on i want to insert from datagrid cells and save it in database and user fills multiple rows and their cells so how do i do it so that user can enter the data in datagridview and save it and how should i run the sql query multiple times to insert multiple rows of data of a particular id..can any body guide me through this