make a simple word factory in vb 10, is it possible?

I am beginner in vb 10 and I planned to create a game in vb which is word factory.
but i don't know where to start. the only flow that i think is there should be a dictionary text file. then in vb from there are tiles of picture boxes that contain letter images. then if the letters are clicked, there will be a string variable that holds the value of clicked letter and read in file dictionary text file. then the score will increase if the sequence of clicked letter images are valid word in the dictionary file. may be it is possible but i don't know how to make it. do you have an idea on how to do this? even the flow of this game.